Li-Lin Du, Ph.D. - Scientists&Research - 北京生命科学研究所

Li-Lin Du, Ph.D.

Investigator, NIBS, Beijing, China

Phone：010-80726688-8505

Fax： 010-80726689

E-mail：dulilin@nibs.ac.cn

Education


1992	B.Sc., Department of Biology, Nankai University, China
1995	M.Sc., Shanghai Institute of Biochemistry, Chinese Academy of Sciences, China
2001	Ph.D., Department of Molecular Biophysics & Biochemistry (MB&B), Yale University, USA

Professional Experience

2001-2007	Postdoctoral Research Associate in Dr. Paul Russell's lab at The Scripps Research Institute (TSRI), USA
2007-2013	Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2013-2021	Associate Investigator, National Institute of Biological Sciences, Beijing, China
2021.6	Investigator, National Institute of Biological Sciences, Beijing, China

Research Description:

We use the fission yeast Schizosaccharomyces pombe as a model system. Working with fission yeast has many advantages, including the ease of genetics and cell biology, availability of powerful functional genomics tools, and extensive homology between its genes and human genes.

We are carrying out research on the following topics:

1. Studying the mechanisms of DNA double strand break repair.

2. Dissecting the molecular machineries of autophagy and related trafficking pathways.

3. Systematic screening of genetic interactions.

Representative Publications

1. Zhao D, Zou C-X, Liu X-M, Jiang Z-D, Yu Z-Q, Suo F, Du T-Y, Dong M-Q, He W, Du L-L (2020). A UPR-induced soluble ER-phagy receptor acts with VAPs to confer ER stress resistance. Mol. Cell 79:963

2. Li J, Wang H-T, Wang W-T, Zhang X-R, Suo F, Ren J-Y, Bi Y, Xue Y-X, Hu W, Dong M-Q, Du L-L (2019). Systematic analysis reveals the prevalence and principles of bypassable gene essentiality. Nat. Commun. 10:1002

3. Liu X-M, Yamasaki A, Du X-M, Coffman VC, Ohsumi Y, Nakatogawa H, Wu J-Q, Noda NN^#, Du L-L^# (2018). Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein. eLife 7:e41237 (^#co-corresponding authors).

4. Hu W, Jiang Z-D, Suo F, Zheng J-X, He W-Z, Du L-L (2017). A large gene family in fission yeast encodes spore killers that subvert Mendel’s law. eLife 6:e26057.

5. Wei Y, Diao L-X, Lu S, Wang H-T, Suo F, Dong M-Q, Du L-L (2017). SUMO-targeted DNA translocase Rrp2 protects the genome from Top2-induced DNA damage. Mol. Cell 66:581–596.

6. Liu X-M, Sun L-L, Hu W, Ding Y-H, Dong M-Q, Du L-L (2015). ESCRTs cooperate with a selective autophagy receptor to mediate vacuolar targeting of soluble cargos. Mol. Cell 59:1035-1042.

7. Zhang J-M, Liu X-M, Ding Y-H, Xiong L-Y, Ren J-Y, Zhou Z-X, Wang H-T, Zhang M-J, Yu Y, Dong M-Q, Du L-L (2014). Fission yeast Pxd1 promotes proper DNA Repair by activating Rad16(XPF) and inhibiting Dna2. PLoS Biol. 12:e1001946.

8. Sun L-L, Li M, Suo F, Liu X-M, Shen E-Z, Yang B, Dong M-Q, He W-Z, and Du L-L (2013). Global analysis of fission yeast mating genes reveals new autophagy factors. PLoS Genet. 9: e1003715.

9. Zhou Z-X, Zhang M-J, Peng X, Takayama Y, Xu X-Y, Huang L-Z, and Du L-L (2013). Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method. Genome Res. 23: 705-715.

10. Han TX, Xu X-Y, Zhang M-J, Peng X, and Du L-L (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing. Genome Biol. 11: R60.